FGF-2 Polyclonal Antibody
¥680.00
CATL1 (heavy chain, Cleaved-Ala114) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2600115
- 产品信息
商品描述
靶点-Target
Cathepsin L
反应性
Human,Rat,Mouse,
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
25kD,37kD
推荐稀释比
WB 1:1000-2000;ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human CATL1 (heavy chain, Cleaved-Ala114)
特异性
This antibody detects endogenous levels of Human CATL1 (heavy chain, Cleaved-Ala114, protein was cleaved amino acid sequence between 113-114 )
基因名称
CTSL1 CTSL
蛋白名称
CATL1 (heavy chain, Cleaved-Ala114)
别名
Cathepsin L1;Major excreted protein;MEP;[Cleaved into: Cathepsin L1 heavy chain;Cathepsin L1 light chain]
Organism-1
Human
基因ID-1
1514
SwissProt-1
P07711
Organism-2
Mouse
基因ID-2
13039
SwissProt-2
P06797
Organism-3
Rat
基因ID-3
25697
SwissProt-3
P07154
背景
catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Dimer of a heavy and a light chain linked by disulfide bonds.,
细胞定位
Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). .
