FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Caspase-2
反应性
Human,Rat,Mouse,
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
12kD,50kD
推荐稀释比
WB 1:1000-2000;ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human Caspase 2 (p12, Cleaved-Ala348)
特异性
This antibody detects endogenous levels of Human Caspase 2 (p12, Cleaved-Ala348, protein was cleaved amino acid sequence between 347-348)
基因名称
CASP2 ICH1 NEDD2
蛋白名称
Caspase2
别名
Caspase-2;CASP-2;Neural precursor cell expressed developmentally down-regulated protein 2;NEDD-2;Protease ICH-1;[Cleaved into: Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12]
Organism-1
Human
基因ID-1
835
SwissProt-1
P42575
Organism-2
Mouse
基因ID-2
12366
SwissProt-2
P29594
Organism-3
Rat
基因ID-3
64314
SwissProt-3
P55215
背景
alternative products:Isoforms differ in the N- and C-termini,catalytic activity:Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.,PTM:The mature protease can process its own propeptide, but not that of other caspases.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.,tissue specificity:Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.,
