FGF-2 Polyclonal Antibody
¥680.00
Cleaved-Notch 1 (V1754) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2600060
- 产品信息
商品描述
靶点-Target
Notch-1
反应性
Human,Mouse,Rat
应用
WB,IF,IHC,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
110kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;IF 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Notch 1. AA range:1735-1784
特异性
Cleaved-Notch 1 (V1754) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 1 protein resulting from cleavage adjacent to V1754.
基因名称
NOTCH1
蛋白名称
Neurogenic locus notch homolog protein 1
别名
NOTCH1;TAN1;Neurogenic locus notch homolog protein 1;Notch 1;hN1;Translocation-associated notch protein TAN-1
Organism-1
Human
基因ID-1
4851
SwissProt-1
P46531
Organism-2
Mouse
基因ID-2
18128
SwissProt-2
Q01705
Organism-3
Rat
SwissProt-3
Q07008
背景
notch 1(NOTCH1) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymph
细胞定位
Cell membrane ; Single-pass type I membrane protein .; [Notch 1 intracellular domain]: Nucleus . Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. .
